Acute toxicity and antithrombotic effect of Xunengda Tablets on mice / 中成药
Chinese Traditional Patent Medicine
; (12)1992.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-681995
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To determine the maximal tolerance of Xunengda Tablets on mice and explore curative effects of its antithrombotic effect and provide the theoretical basis for selecting drugs.Methods:
Mice were given maximal dose, 26g?kg -1 of body weight, XND Ig once; Divided 53 mice into five groups, they were administered XND tab.(3g?kg -1 ), RSC(1.25g?kg -1 ), CDDP(1.25g?kg -1 ), XSTL(2.5g?kg -1 ), and NS once daily for 7 days, repectively; 1h after treatment the seventh day, the animals of groups iv. were given collagen adr by producing whole organism thrombus, observing the mortality, They were determined coagulation time with the blood capillaries and the number of writhings per mouse was recorded in order to determine pain.Results:
Maximal tolerance (Ig) is 26g?kg -1 , 886.7 times the dose of clinical application apart from XSTL, three kinds of drug showed the avidence of antithrombotic effect ( P
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional Patent Medicine
Ano de publicação:
1992
Tipo de documento:
Artigo