The Prevalence of Hepatitis G Virus by Reverse Transcription-Polymerase Chain Reaction / 대한임상미생물학회지
Korean Journal of Clinical Microbiology
; : 82-88, 1999.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-68227
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Hepatitis G virus(HGV) is known to be associated with non-A-E hepatitis but pathogenic relevance and mode of transmission are still unclear. In this study, we analyzed the prevalence and clinical implicati ons of HGV infection in patients on hemodialysis or being treated for hematologic disease, and healthy controls.METHODS:
HGV RNA was identified in serum by reverse transcription-polymerase chain reaction(RT-PCR) with nested primers deduced from highly conserved area of the 5'-untranslated region. Other parenterally transmissible hepatitis viral markers(HBsAg and anti-HCV) and alanine aminotransferase(ALT), history of transfusion, duration of hemodialysis were assessed.RESULTS:
HGV RNA was detected in 12.5%(8 of 64) of the patients on hemodialysis and in 24.1%(14 of 58) of the patients treated for hematologic disease, as compared with 0.8%(1 of 120) of healthy controls(P<0.05). HBsAg, anti-HCV, ALT level, rate of transfusion history and duration of hemodialysis were not significantly different between HGV-infected patients and non-HGV-infected patients. In patients treated for hematologic disease, sex was significantly different between HGV positive and negative groups.CONCLUSIONS:
Patients on hemodialysis and being treated for hematologic disease have increased risk for HGV infection, but there was no clinical difference between HGV RNA positive and negative groups. HGV infection itself does not seem to be a frequent cause of liver disease in these patients. The clinical significance of long-term infection with HGV remains to be established.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
RNA
/
Prevalência
/
Diálise Renal
/
Vírus GB C
/
Alanina
/
Doenças Hematológicas
/
Hepatite
/
Antígenos de Superfície da Hepatite B
/
Hepatopatias
Tipo de estudo:
Estudo de prevalência
Limite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Clinical Microbiology
Ano de publicação:
1999
Tipo de documento:
Artigo