Effects of puerarin on MDA and MPO in myocardial in earlier period of scalded rats / 中华急诊医学杂志

ABSTRACT

Objective To observe the effect of puerarin on the level of malondialdehyde (MDA) and myeloperoxidase (MPO) in myocardial in scalded rat.Methods Eighty-eight Wistar rats were randomly divided into the recovery group (group R,n=40),the treatment group (group T,n=40) and the control group (group C,n=8) . The rats in the recovery and the treatment groups were subjected to 30% TBSAⅢdegree scald.Myocardial tissue samples from the group R and group T were harvested at 1,3,6,12,24 postburn hours for the determination of MDA and MPO. The morphological change in the myocardial tissue was observed with transmission electronic microscope.Results (1)In group R,MDA、MPO went up 1 hours after burns,and all attaining the top at 12 hours post burn (P＜0.01).(2)In group T,the indexes above had the same trends as group R.But comparing with group R,MPO and MDA were much lower at 1,3,6,12 hours (P＜0.05 or P＜0.01).(3)Comparing with group R,the altrastructural changes were obviously alleviated at 24 hours in group T.Conclusion The production of MDA,MPO in severely burned rats can be inhibited by puerarin,which was beneficial in the management of myocardial injuries after severe burns.