Influence of gender differences on nuclear factor-kappa B activation in livers in septic rats / 中华急诊医学杂志
Chinese Journal of Emergency Medicine
; (12)2006.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-682738
Biblioteca responsável:
WPRO
ABSTRACT
Objective To investigate the influence of gender differences on NF-kB activation in livers in septic rats. Methods Total 20 female and 20 male Wistar rats were randomly divided into four groups.Tissue samples of the livers were collected to measure NF-kB activation by EMSA.The level of plasma ALT,TNF-?and estrogen were measured also. Results NF-kB activation in normal male and female rats has no significant difference (P>0.05).After stimulated by LPS,the level of NF-kB activation and ALT,TNF-?in plasma were markedly upregulated,and the index of female group lower than that in male group (P<0.01).The level of NF-kB activation in livers and ALT,TNF-?in plasma both in male and female have significantly negative correlation with the level of estrogen in plasma (P<0.05 ).Conclusion There are significantly gender differences on NF-kB activation in livers in septic rats.Estrogen may decrease the injury of livers in septic rats.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Aspecto:
Determinantes sociais da saúde
Idioma:
Chinês
Revista:
Chinese Journal of Emergency Medicine
Ano de publicação:
2006
Tipo de documento:
Artigo