Research on the antitumor actions of extracts from the fruiting body of coriolus versicolor / 医学研究生学报
Journal of Medical Postgraduates
; (12)2003.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-684473
Biblioteca responsável:
WPRO
ABSTRACT
Objective:
To investigate the antitumor actions of polysaccharide extracts from the fruiting body of coriolus versicolor (CVE).Methods:
Hepatoma HepA cells were injected into mice subcutaneously. Different doses of CVE were given by gavage. On the 7 th and 14 th day, tumor inhibitive rates were calculated. ELISA was performed to measure the serum IgG level; MTT was used to examine CVE′s effects on the proliferation of T lymphocytes of thymus. Immunohistochemistry was used to determine CVE′s influence on the expression of tumor related genes P53 and VEGF in liver.Results:
CVE may evidently inhibit the growth of the transplanted HepA tumors. Its effects on the serum IgG level and on the proliferation of T lymphocytes of thymus were also significantly. Also, CVE markedly decreased the expression of P53, VEGF genes in liver. Conclustion CVE had significant antitumor effects in vivo . The mechanisms may involve immune modulation effects and antimetastasis actions.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Medical Postgraduates
Ano de publicação:
2003
Tipo de documento:
Artigo