Study of mitochondrial DNA A1555G mutation among nonsyndromic hearing impairment in Chinese population / 中华检验医学杂志
Chinese Journal of Laboratory Medicine
; (12)2001.
Article
em Zh
| WPRIM
| ID: wpr-685327
Biblioteca responsável:
WPRO
ABSTRACT
Objective To study the prevalence of the mtDNA A1555G gene mutation in Chinese population with nonsyndromic hearing impairment.Methods PCR-RFLP,directional sequencing of PCR products were applied in 325 patients with nonsyndromic hearing impairment and 50 normal controls.Results The mutation rate of the mtDNA A1555G was 14.5% (47/325),28 of 47 cases were homozygosis,19 of 47 cases were heterozygosis.The same mutation was not detected in the control subjects.Conclusion The mutation rate of the mtDNA A1555G is relatively high in the Chinese NSHI patients,the mutation type includes both heterozygosis and homozygosis.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Laboratory Medicine
Ano de publicação:
2001
Tipo de documento:
Article