Topical Tacrolimus Resulting in a Marked Resolution of Perianal Crohn's Disease / 대한소아소화기영양학회지
Korean Journal of Pediatric Gastroenterology and Nutrition
; : 70-75, 2005.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-68799
Biblioteca responsável:
WPRO
ABSTRACT
Crohn's disease of the perineum is notably resistant to treatment. We describe our experiences of tacrolimus ointment application in three patients with intractable perianal Crohn's disease. At the time of diagnosis patients showed anal fissure with ulcer, anal fistula, or perianal abscess, respectively. These lesions did not respond to steroid, metronidazole, mesalazine, or azathioprine, though the pediatric Crohn's disease activity index was markedly improved during the treatment period (4 to 12 months). Topical tacrolimus was applied and resulted in marked healing and a rapid granulation of cavity edges within 6 weeks to 3 months. Topical tacrolimus at a low dose shows a promise for the management of childhood perianal Crohn's disease. Further controlled studies are required to assess the efficacy and safety of this treatment.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.2: Reduzir as mortes de recém nascidos e crianças com menos de 5 anos
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Períneo
/
Azatioprina
/
Doença de Crohn
/
Tacrolimo
/
Mesalamina
/
Diagnóstico
/
Abscesso
/
Fissura Anal
/
Fístula
/
Metronidazol
Tipo de estudo:
Estudo diagnóstico
Limite:
Criança
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Pediatric Gastroenterology and Nutrition
Ano de publicação:
2005
Tipo de documento:
Artigo