Research Progress on Metabolic Regulatory Mechanisms of Hematopoietic Stem Cells -Review / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 917-921, 2018.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-689553
Biblioteca responsável:
WPRO
ABSTRACT
Hematopoietic stem cells (HSC) are a class of stem cells with self-renewal and multipotent differentiation into a variety of blood cells and are most thoroughly studied, maturely applied in the clinic adult stem cell. Function of HSC is closely associated with metabolic regulation. The metabolic state mainly maintains HSC living in hypoxic bone marrow microenvironment depending on glycolysis for energy metabolism, and keeping low reactive oxygen species (ROS) level. Proteins like Hif-1, FoxO3, ATM, PTPMT1 protect HSC from ROS injury, maintaining HSC in hypoxic state. In addition, glucose metabolism-related enzymes, glutamine, fatty acid oxidation, purine and amino acid metabolism also play important roles in metabolic regulation of HSC. In this review the research progress on metabolism regnlation mechanisms of HSC is summurized, focusing on the mechanisms releted with oxydation metabolism regulation, carbohydrate metabolism level, purine metabolism and aminoacide metabolism.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Oxirredução
/
Medula Óssea
/
Células-Tronco Hematopoéticas
/
Diferenciação Celular
/
Espécies Reativas de Oxigênio
Idioma:
Chinês
Revista:
Journal of Experimental Hematology
Ano de publicação:
2018
Tipo de documento:
Artigo