Clinical application of minimal residual disease detection in childhood acute leukemia / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 416-420, 2018.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-689615
Biblioteca responsável:
WPRO
ABSTRACT
In recent years, great progress has been made in the treatment outcome of childhood acute leukemia with the improvement of chemotherapy regimens and the introduction of risk-stratified therapy; however, minimal residual disease (MRD) is still a difficult problem which affects the prognosis of acute leukemia. MRD influences the selection of chemotherapy regimens and recurrence risk stratification, and meanwhile, it can be used for prognostic prediction. At present, flow cytometry and polymerase chain reaction are mainly used for MRD detection. The next-generation sequencing also plays an important role in MRD detection, especially in MRD detection after stem cell transplantation. This article reviews the methodology and significance of MRD detection in childhood acute leukemia.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Terapêutica
/
Leucemia Mieloide Aguda
/
Neoplasia Residual
/
Transplante de Células-Tronco Hematopoéticas
/
Diagnóstico
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Sequenciamento de Nucleotídeos em Larga Escala
Tipo de estudo:
Estudo diagnóstico
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Chinês
Revista:
Chinese Journal of Contemporary Pediatrics
Ano de publicação:
2018
Tipo de documento:
Artigo