Advances in studies on susceptibility genes of bronchial asthma / 国际儿科学杂志

ABSTRACT

Asthma is a chronic inflammatory disease in the respiratory tract,which is composed of eosinophils,mast cells,T cells,airway epithelial cells and other inflammatory cells.Globally,the incidence of the disease increases year by year,which brings heavy health and financial burden to the patients,their families and the society.At present,much progress has been made in the study of asthmatic susceptibility genes with advances in genome-wide association studies(GWAS) and whole genome sequencing(WGS).This article describes the new development of asthma susceptibility genes and gene testing methods,to illustrate the association between asthma phenotypes and susceptibility genes.Some genes,such as interleukin-33 (IL-33)and thymic stromal lymphopoietin(TSLP),are likely to be potential biomarkers.These studies have certain guiding significance for the diagnosis and treatment of asthma.