Advances in the evaluation of anthracycline-induced cardiotoxicity in children with malignant tumors / 国际儿科学杂志

ABSTRACT

Anthracyclines are a class of chemotherapeutic drugs derived from Streptomyces faecalis,which are non-specific cytotoxic drugs in the cell cycle.They are widely used as fast-line chemotherapeutic drugs for the treatment of childhood leukemia,lymphoma,solid tumors and have a broad anti-tumor effect.However,side effects caused by anthracyclines included cardiotoxicity,myelosuppression,alopecia,etc,especially cardiotoxicity is often progressive and irreversible,strongly affecting the long-term quality of life of children.The early detection,diagnosis and corresponding intervention of anthracycline-induced cardiotoxicity are the research hotspots of clinical heart damage.There are many methods for monitoring the anthracycline-induced cardiotoxicity.How to effectively monitor the anthracycline-induced cardiotoxicity is particularly important.This article reviews the progress about the evaluation of anthracycline-induced cardiotoxicity.