Research on overlapping infection of infectious diseases related to blood transfusion in Hubei province / 国际检验医学杂志

ABSTRACT

Objective To analyze the results of serum makers of transfusion-related infectious diseases in Hubei Province and the surrounding areas,in order to understand the patient′s infection status,thereby avoi-ding or reducing medical disputes,and providing reference data for the prevention and treatment of transfu-sion-related infectious diseases,especially AIDS and syphilis.Methods 60 570 pretransfusion patients from 2011 to 2016 in Hubei Province and surrounding areas were selected as the study group.Meanwhile,19 800 pretransfusion patients from 2001 to 2003 in Hubei Province and surrounding areas were selected as control group.Chemiluminescence detection was used to examine human immunodeficiency virus (HIV),hepatitis B virus (HBV),hepatitis C virus (HCV) and treponema pallidum (TP) serum markers.Different period pre-transfusion patients′infection status,route of transmission and distribution characteristics of transfusion-re-lated infectious diseases were compared.Results In the study group,44 cases (0.07%) were HIV positive, and there was no statistical difference compare with the control group (P>0.05);1 091 cases were TP posi-tive (1.80%),7 607 cases were positive for HBV (12.56%),and 1 062 cases were HCV positive(1.75%), and there were statistically significant differences compared with the control group (P<0.05).In addition, there were 8 cases of HIV and TP double infection,10 cases of HIV and HBV double infection,4 cases of HIV and HCV double infection;3 cases of HIV,T P and HBV triple infection,4 cases of HIV,T P and HCV triple infection,1 case of HIV and HBV,HCV triple infection in the study group;and compared with the control group,it showed an increasing trend (P<0.05).Conclusion The status of transfusion-related infectious dis-eases in Hubei Province and surrounding areas is still severe.Some patients have been infected with HIV,TP, HBV or HCV before hospitalization,and a few have even had double or triple infection.Clinic should further strengthen the prevention and control of transfusion-related infectious diseases,especially for HIV and TP, and reduce the spread of transfusion-related infectious diseases in the general population.