Research progress of the mechanism of double negative T cell in the treatment of pancreatic tumor / 国际外科学杂志

ABSTRACT

Double negative T cell is a kind of special regulatory T cell with a cell phenotype of TCR + CD3 + CD4-CD8-.It plays an important role in many diseases such as autoimmune diseases,tumor immunity,transplant rejection and allergic diseases by expressing unique surface markers and secreting unique effector factors.Pancreatic cancer is a poorly diagnosed malignant tumor of the digestive system,and its early diagnosis rate is not high,the treatment is still based on radical tumor resection.Although the surgical technique is continuously improved,the 5-year survival rate has not improved significantly.At present,there is still a lack of effective treatment.In recent years,double negative T cell has become a new research hotspot in tumor immunity,bringing new hope for the treatment of pancreatic cancer.According to different types of T cell antigen receptor (TCR) expression,double negative T cell can be divided into TCRαβT cell and TCRγδT cell.This review focuses on the source of double negative T cell and possible molecular mechanisms in cancer therapy.