Effects of Kanglaite injection combined with NP chemotherapy for immune status,inflammatory factors and quality of life of patients with advanced NSCLC / 国际肿瘤学杂志

ABSTRACT

Objective To investigate the effect of Kanglaite injection combined with NP (navelbine +cisplatin)chemotherapy for immune status,inflammatory factors and quality of life of patients with advanced non-small cell lung cancer (NSCLC). Methods A total of 106 patients with advanced NSCLC admitted to our hospital from June 2014 to January 2017 were divided into control group and observation group according to ad-mission even and odd numbers,and 53 cases in each group. The patients in control group received chemothera-py with NP regimen,and the patients in observation group received Kanglaite injection + NP regimen chemo-therapy. The immune status,inflammatory factors and quality of life of the patients in the two groups were ob-served and compared statistically. Results After treatment,the immune indexes including CD3 +(62. 64％ ± 3. 96％ vs. 54. 08％ ± 7. 19％),CD4 +(37. 10％ ± 5. 09％ vs. 29. 22％ ± 6. 38％),CD4 + / CD8 +(1. 96 ± 0. 62 vs. 1. 12 ± 0. 39)and natural kill cells (22. 45％ ± 5. 92％ vs. 16. 37％ ± 6. 13％)of observation group were apparently higher than those of control group (t = 7. 592,P < 0. 001;t = 7. 029,P < 0. 001;t = 8. 349, P < 0. 001;t = 5. 194,P < 0. 001). After treatment,the levels of interleukin-6 [(80. 56 ± 10. 27)ng/ L vs. (102. 87 ± 14. 58)ng/ L],tumor necrosis factor-α [(8. 35 ± 2. 73)ng/ L vs. (15. 69 ± 3. 14)ng/ L],C-re-active protein [(9. 18 ± 2. 38)mg/ L vs. (13. 84 ± 2. 92)mg/ L]of observation group were significantly lower than those of control group (t = 9. 107,P < 0. 001;t = 12. 843,P < 0. 001;t = 9. 006,P < 0. 001). The im-proved condition of Karnofsky performance status score of observation group was significantly better than that of control group (Z = 3. 133,P = 0. 002). The effective rate of observation group was significantly higher than that of control group (58. 49％ vs. 35. 85％),with significant difference (χ2 = 5. 451,P = 0. 020). Conclu-sion The efficacy of Kanglaite injection combined with NP regimen in the treatment of advanced NSCLC is positive,which can effectively improve the immune status of patients,reduce inflammatory reaction and improve quality of life.