Roles of Gut Microbiota on Occurrence and Development of Colorectal Cancer and Effects of Chinese Herbal Medicine Intervention / 世界科学技术-中医药现代化

ABSTRACT

Colorectal cancer (CRC) is one of the most common malignant tumors.Accumulating evidences suggests that gut microbiota play an important role in CRC initiation and progression.Chinese herbal medicine has certain regulation effects on disorders of gut microbiota.In current review,we discuss the changes of gut microbiota in CRC patients,and summarize the effects of gut microbiota on CRC progression and their underlying mechanisms through barrier function,inflammation,bacterial enzymes,toxic metabolites,as well as the effects of Chinese herbal medicine on gut microbiota.This review provides a basic scientific and clinical application of gut microbiota in CRC.