Localized Scleroderma-like Reaction Induced by Doxifluridine / 대한피부과학회지
Korean Journal of Dermatology
; : 95-97, 2009.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-69666
Biblioteca responsável:
WPRO
ABSTRACT
Exogenous factors, including environmental substances and drugs, are known to induce scleroderma-like reactions. Various scleroderma-like reactions induced by anti-cancer drugs have recently been reported. This is the first report that doxifluridine (Didox), an oral prodrug of the antineoplastic agent 5-fluorouracil (5-FU), induced a localized sclerderma-like reaction. A 51-year-old woman was referred to our clinic with multiple pearly, shiny patches on both her breasts, her pelvis and her back. After surgical excision and radiation therapy due to her right breast cancer, she took Didox for 7 months. A skin biopsy specimen revealed that the dermal collagen thickening extended even to the subcutaneous tissue. The routine laboratory tests were within the normal ranges and the tests for antinuclear antibody (ANA), anti SS-A antibody, anti SS-B antibody and anti U1-RNP antibody were all negative. After discontinuation of Didox, the lesions gradually improved. Based on these finding, we diagnosed this case as a localized scleroderma-like reaction induced by doxifluridine and we should pay attention to detect this adverse effect of the long term use of doxifluridine.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pelve
/
Valores de Referência
/
Pele
/
Biópsia
/
Mama
/
Neoplasias da Mama
/
Anticorpos Antinucleares
/
Colágeno
/
Floxuridina
/
Tela Subcutânea
Limite:
Feminino
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2009
Tipo de documento:
Artigo