Effects of moderate acute normovolemic hemodilutionon on the cerebral oxygenation in patients undergo-ing laparoscopic radical prostatectomy / 实用医学杂志

ABSTRACT

Objective To observe the effect of moderate acute normovolemic hemodilutionon(ANH)on the cerebral oxygenation in patients undergoing laparoscopic radical prostatectomy. Methods Sixty patients receiv-ing laparoscopic radical prostatectomy were randomly and equally divided into control group and observation group. Patients of observation group were received ANH,but patients of control group were received routine infusion.The artery and the ball portion of the internal jugular vein blood were sampled for blood gas analysis at the time points of 10min after intubation(T1),10 min after ANH(T2),30 min(T3)after pneumoperitoneum and Trendelenburg po-sition,the end of surgery(T4). To calculate oxygen content of arterial,and the hall portion of the internal jugular vein,cerebral oxygen uptake rate,the arterial internal jugular vein bulbar oxygen differenceand lactate difference between the artery and vein,oxygen saturation of internal jugular vein bulbar,to record the bleeding volume,the cases and volume of blood transfusion.Results observation group were not transfuse any allogeneic blood,the vol-ume and cases of allogeneic blood transfusion of control group were significant higher than observation group(P <0.05).The Da-jvO2of observation group were significant lower than those of control group at T2and T3(P<0.05). There were no significant difference between the two groups of SjvO2、CERO2and VADL(P > 0.05). Conclusions The application of moderate acute normovolemic hemodilutionon in patients undergoing laparoscopic radical prosta-tectomy can effectively decrease the volume of allogeneic blood transfusion,don't infect the oxygen providing of brain and the cerebral oxygenation.