An Analysis of 14 Cases of the Temporal Bone Langerhans Cell Histiocytosis in Children / 听力学及言语疾病杂志

ABSTRACT

Objective To study the clinical characteristics of the Langerhans cell histiocytosis (LCH ) of the temporal bone in children .Methods A total of 14 children with LCH of the temporal bone at Wuhan Children's Hospital were retrospectively reviewed from June 2011 to December 2016 .The clinical data ,imaging findings ,diag-nosis ,treatment and prognosis were studied .The correlation between clinical classifications and prognosis was also analyzed .Among the 14 patients ,5 were girls and 9 were boys .Eight cases were the single system group (3 cases as the single temporal bone ,5 case as the multifocality ) ,and 6 case as the multisystem group .Results The most common clinical characteristics of LCH were temporal tumors ,otorrhea ,otalgia ,hearing loss and the granulation of external auditory canals .The followed-up was for 1～5 years .Four cases were regressive ,l case kept stable ,while 2 cases showed progressive .The prognosis in the multisystem group was significantly worse than the single system group(P<0 .05) .Conclusion The most of temporal bone LCH involves the single system ,while temporal tumor and otorrhea are common as the first signs of temporal bone LCH .The imaging examination remains as the major di-agnosis method .The differential diagnosis focuses on the common ear infection and otic neoplasms .The diagnosis is based on histological and immunophenotypic examination of the lesion tissue .The prognosis of the single system group is much better than the multisystem group .