The value of S100βprotein and electroencephalogram in cerebral function monitoring of critically ill children / 中国小儿急救医学

ABSTRACT

Objective To investigate the value of S100β protein and electroencephalogram ( EEG) in cerebral function monitoring of critically ill children. Methods Sixty critically ill children admitted in our department from September 2014 to December 2016,were divided into 2 groups according to pediatric critical illness score ( PCIS) ,30 cases in critical group ( PCIS≤80 scores) and 30 cases of non critical group ( PCIS>80 scores) . Serum samples were collected from the 60 cases at 24 h,72 h and 1 week after admission, respectively. The serum S100β protein and EEG were dynamically monitored on 3 time points. ELISA was used to test the content of S100βprotein of collected samples. Results There was no statistically significant difference in gender and age between critical group and non critical group[ male/female22/8 vs. 21/9;age(3. 68 ± 1. 37)years vs. (2. 52 ± 0. 86)years,P>0. 05]. The glasgow score of critical group was lower than that of non critical group(8. 67 ± 1. 83 vs. 13. 05 ± 2. 94,P<0. 05). Serum S100βprotein contents of critical group were(112. 55 ± 29. 20)μg/L,(120. 86 ± 17. 10)μg/L,and (279. 82 ± 28. 80)μg/L) at 24 h,72 h and 1 week respectively, which were obviously higher than those of non cricical group [ ( 0. 51 ± 0. 06 )μg/L, (0. 32 ± 0. 03)μg/L,(0. 34 ± 0. 05)μg/L](P<0. 05). Meanwhile,the abnormal rate of EEG monitoring of critical group were 19 cases ( 63. 3％) , 18 cases ( 60. 0％) , 20 cases ( 66. 7％) at 24 hours, 72 hours and 1 week respectively,which were also obviously higher than those of non critical group [ 9 cases ( 30. 0％) , 7 cases(23. 3％),6 cases(20. 0％)](P<0. 05). Conclusion Both serum S100β protein and dynamically EEG monitoring contribute to detect the status of cerebral injury in early stage, with significant value in cerebral function monitoring of critically ill children.