Expression of Pim1 protein in variant lesions of esophagus and its clinical significance / 新乡医学院学报

ABSTRACT

Objective To study the expression of Pim1 protein in variant lesions of esophagus and its correlation with the clinicopathological parameters of esophageal cancer patients.Methods The esophageal biopsy specimens of 182 cases,including 37 cases of normal squamous epithelium,43 cases of low-grade intraepithelial neoplasia,31 cases of high-grade intraepithelial neoplasia,71 cases of esophageal squamous cell carcinoma were collected in the Third Affiliated Hospital of Xinxiang Medical University From January 2009 to March 2016.The expression of Pim1 protein in all esophageal tissues was detected by immunohistochemical method,and the correlation between Pim1 protein expression and clinicopathological parameters of esophageal squamous cell carcinoma patients was analyzed.Results The higher expression rate of Pim1 protein in esophageal normal squamous epithelium,low-grade intraepithelial neoplasia,high-grade intraepithelial neoplasia and esophageal squamous cell carcinoma was 24.3％ (9/37),62.8 ％ (27/43),70.9％ (22/31),and 76.1％ (54/71),respectively.The higher expression rate of Pim1 protein in the tissue of low-grade intraepithelial neoplasia,high-grade intraepithelial neoplasia and esophageal squamous cell carcinoma was significanlty higher than that in the esophageal normal squamous epithelium(x2 =11.89,14.79,26.70;P ＜ 0.05);there was no statistic difference of the higher expression rate of Pim1 protein in the tissue of low-grade intraepithelial neoplasia,high-grade intraepithelial neoplasia and esophageal squamous cell carcinoma (P ＜ 0.05).The expression of Pim1 protein was significantly positively correlated with lymph node metastasis and TNM stage(P ＜0.05),but not correlated with age and histological grade of patients (P ＜ 0.05).Conclusion The expression of Pim1 protein is closely related to the occurrence and development of esophageal cancer.