Animal models of oxygen-induced retinopathy / 中华实验眼科杂志

ABSTRACT

Models of oxygen-induced retinopathy (OIR) have been built on several animals,including kitten,mouse,rat,rabbit,puppy and zebrafish.These models play an important role in studying the mechanisms and treatments of retinal neovascularization,which is partially mimicking the pathological process of retinopathy of prematurity (ROP) and proliferative diabetic retinopathy (PDR).As the extensive application of transgenic technology,animal models of OIR will provide more evidences on investigating the retinal angiogenic diseases.However,none of these OIR models is perfect to simulate human ROP completely,which still needs more comprehensive and profound exploration.