Study on Egr2/Egr3 and autoimmune diseases / 医学研究生学报
Journal of Medical Postgraduates
; (12): 524-528, 2018.
Artigo
em Chinês
| WPRIM (Pacífico Ocidental)
| ID: wpr-700866
Biblioteca responsável:
WPRO
ABSTRACT
Early growth response protein (Egr) belongs to the immediate response factor , whose family members include Egr1, Egr2, Egr3 and Egr4.The Egr protein is mainly involved in the growth ,differentiation and apoptosis of cells .It is reported the Egr2/Egr3 protein can not only effect the T /B cell's proliferation and differentiation, but also participate in multiple signaling path -ways, such as JAK/STAT and NF-κB).With the in-depth study, it is found that Egr2 and Egr3 have an indispensable relationship with the occurrence of various autoimmune diseases , including Systemic Lupus Erythematosus , Scleroderma, etc.Therefore, Egr2 and Egr3 may be a potential therapy target for autoimmune diseases .This paper reviews the biological effects of Egr 2/Egr3 and its research pro-gress in relation to autoimmune diseases .
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Medical Postgraduates
Ano de publicação:
2018
Tipo de documento:
Artigo