Anaiysis of Clinical Manifestations and Risk Factors of Mortality due to Acinetobacter Baumannii Positive Pulmonary Infection in ICU / 医学研究杂志

ABSTRACT

Objective To analyze the clinical manifestations,bacterial resistance to antibiotics and risk factors of mortality in pneumonia patients with Acinetobacter baumannii(AB) positive in respiratory secretions.Methods Clinical datas of pneumonia patients with AB positive in respiratory secretions in ICU from June 2012 to June 2017 were analyzed.According to the 28 day survival after diagnosis,the patients were divided into death group and survival group.Univariate and multivariate Logistic analysis were used to examine the risk factors of AB positive patients.Results This study included 98 patients.The 28 day mortality was 54.1％.The independent risk factors of mortality weremerge coronary heart disease(OR =38.3,95％ CI1.81-720.10,P =0.019),high APACHE Ⅱ score (OR =3.47,95％ CI1.30-12.81,P=0.043),prolonged APTT(OR =1.32,95％ CI1.03-1.71,P=0.037),high levels of PCT(OR=2.78,95％ CI1.30-7.02,P =0.023).APACHE Ⅱ scores and patients died from AB culture positive time was significantly negative correlation,r =-0.601,P =0.000.Whether the application of antibiotics for AB was not clearly affected by the prognosis.Conclusion Merge coronary heart disease,high APACHE Ⅱ score,prolonged APTT,high levels of PCT are independent risk factors for AB culture positive patients.In particular,merge coronary heart disease and the severity of the underlying disease determine the patient's prognosis.