Pretreatment Conditions in the Detection of Selenium from Hugan Tablets by Central Composite Design-Response Surface Methodology / 医药导报

ABSTRACT

Objective To optimize the pretreatment conditions in the detection of selenium from hugan tablets. Methods The main influential factors of pretreatment conditions included concentration of hydrochloric acid,time in water bath and concentration of potassium ferricyanide solution.The extraction effect was evaluated with the content of selenium.Pretreatment conditions were optimized by central composite design-response surface methodology. Results The best pretreatment conditions was 6 mol·L-1hydrochloric acid,30 minutes of bathing in water bath,20%potassium ferricyanide solution. Conclusion The central composite design-response surface methodology is highly predictive,reasonable and feasible.