Research progresses of neutrophils in tumor immunology / 中国免疫学杂志

ABSTRACT

Neutrophils in the tumor microenvironment have anti-tumorigenic (N1) or pro-tumor igenic (N2) functions.N1 neutrophils are manipulated to have cytotoxicity against tumors;N2 neutrophils can lead to the tumorigenesis,tumor growth,metastasis and tumor angiogenesis by secreting neutrophil elastase,matrix metalloproteinases,cytokines and chemokines.This review summarizes the biological characteristics of N1 and N2 neutrophils in tumor immunology.