Research progress of the association between Hp polymorphism and diabetic vascular complications / 中国糖尿病杂志

ABSTRACT

Haptoglobin (Hp),also known as hemopexin,is an acute phase protein expressed predominantly in the liver.Hp binds to free Hemoglobin (Hb),and this Ht-Hb complex is degraded via CD163 (macrophage scavenger receptor)-mediated endocytosis,which subsequently blocks Hb-induced oxidative damage.There are three major human Hp genotypesHP1-1,HP2-1,and HP2-2.Studies have shown that different HP genotype has distinct impact on diabetic vascular complications.In this review,we focus on the association between HP polymorphisms and diabetic vascular complications.