Meta analysis of stem cells in the treatment of lower extremity ischemic disease / 中国现代普通外科进展

ABSTRACT

Objective:Using Meta analysis comprehensive evaluation of the curative effect of stem cells to treat lower limb ischemic diseases.Methods:Using a computer to retrieve published both at home and abroad literatures about stem cell therapy for lower limb ischemic diseases,after quality evaluation according to certain standard into literature,using RevMan 6.0 software is analyzed.Using the funnel figure,Begg's regression analysis for publication bias estimation between different studies.Results:Participants included 16 studies,including 629 cases of the object of study.Meta analysis results show that the stem cells before,during and after the treatment of lower limb ischemic diseases,TcPO2 statistically significant TcPO2 levels after treatment (WMD=9.27,95％ CI9.27,4.53,P=0.000).Before and after treatment was statistically difference between ABI,ABI levels after treatment (WMD=0.13,95％ CI0.13,0.19,P=0.000).Temperature measurement was statistically difference,temperature measuring levels after treatment(WMD=2.75,95％CI2.75,1.92,P=0.000).Three Meta analysis exists heterogeneity and publication bias results show that the funnel chart is symmetrical,at the same time Begg's regression analysis results showed that no publication bias.CouclusionStem cells to treat lower limb ischemic diseases effectively,the forward security still need massive evidence-based medicine.