Expression of ZIC4 in Endometrial Carcinoma and Its Significance / 中国医科大学学报

ABSTRACT

Objective To investigate zinc finger of the cerebellum 4(ZIC4) expression in endometrial cancer tissue and its relationship with clinicopathological parameters. Methods Immunohistochemistry was used to detect ZIC4 expression in endometrial paraffin specimens. Results The positivity rate of ZIC4 expression in atypical hyperplasia and endometrial carcinoma was higher than that in normal endometrial tissue. ZIC4 expression was correlated with the clinical stage,differentiation,depth of uterine invasion,and lymph node metastasis of endometrial cancer. Survival analysis revealed that patients with endometrial cancer who had low ZIC4 expression levels had better prognosis. Conclusion The ZIC4 expression level in endometrial carcinoma is significantly increased;thus,ZIC4 expression level can be used to monitor the prognosis of patients with endometrial cancer.