Pleurotus citrinopileatus alleviates alcohol-induced fatty liver via upregulating AMPK signaling / 中国药理学与毒理学杂志
Chinese Journal of Pharmacology and Toxicology
; (6): 276-276, 2018.
Article
em Zh
| WPRIM
| ID: wpr-705290
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WPRO
ABSTRACT
OBJECTIVE The current study was designed to investigate the anti-steatosis effect of Pleurotus citrinopileatus extract (PC) and the underlying mechanism in vivo and in vitro. METHODS Acute and chronic alcoholic hepatosteatosis murine models and ethanol-treated HepG2 cells were applied. RESULTS In vitro,the anti-steatosis effect of PC was further confirmed via Nile red staining in HepG2 cells treated with ethanol.Both of acute and chronic alcohol-induced mice hepatosteatosis model,PC decreased serum aminotransferase and triglyceride accumulation. Upregulated sterol-regulatory element binding protein1(Srebp1),purinergic ligand-gated ion channel 7receptor(P2X7R)and downregulated sirtuin1 (SIRT1), adenosine 5′-monophosphate (AMP)-activated protein kinase α (AMPKα) caused by acute and chronic alcohol intake were modulated by PC.In ethanol-exposed HepG2 cells,PC reduced lipid accumulation in a concentration-dependent manner and exhibited superior ability in controlling lipid accumulation compared with metformin. CONCLUSION PC could abolish hepatic lipid accumulation through regulating SIRT1-AMPKα signaling in acute and chronic alcohol-induced hepatic steatosis.
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Base de dados:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Pharmacology and Toxicology
Ano de publicação:
2018
Tipo de documento:
Article