Effect of peripheral blood neutrophil to lymphocyte ratio and high-sensitivity C-reactive protein on recurrence in patients with paroxysmal atrial fibrillation after radiofrequency ablation / 中国综合临床

ABSTRACT

Objective To discuss the efficacy of NLR and hs-CRP levels on recurrence in patients with paroxysmal atrial fibrillation after radiofrequency catheter ablation. Methods Eighty-nine cases of paroxysmal atrial fibrillation treated by radiofrequency ablation in Chaoyang Central Hospital from May 2011 to October 2015 were selected and were divided into the recurrence group and non-recurrence group according to the recurrence. The preoperative NLR and hs-CRP levels were observed,and the correlation between NLR and hs-CRP was analyzed. Logistic regression analysis was used to analyze the risk factors of postoperative recurrence of atrial fibrillation. Results 27 cases were recurred after 1 year follow-up,the recurrence rate was 30. 3%( 27/89) . 27 cases in the recurrence group, 62 cases in the non-recurrence group. The disease duration of the recurrence group and the non-recurrence group were (7. 6±3. 4)years and (5. 3±2. 5) years respectively. The left atrial diameter (LAD) were (39. 09±3. 27) mm and (35. 91±3. 95) mm,NLR were(3. 69±0. 67) and (2. 58±0. 40),hs-CRP were (5. 20±2. 45) mg/L and (3. 09±1. 70) mg/L respectively in the two groups,the differences were statistically significant between the two groups (P＝0.001,0.002,0.004,0.001).Pearson correlation analysis showed that there was a positive correlation between NLR and hs-CRP (r＝0. 58,P＜0. 01). Logistic regression analysis showed that NLR,hs-CRP,LAD were risk factors of recurrence (OR(95%CI)2. 071( 1. 689～ 3. 301 ), 1. 760 ( 1. 096～ 4. 286 ), 1. 943 ( 1. 025～ 3. 607 )) ( P ＝ 0. 019, 0. 030, 0. 035). Conclusion The levels of NLR and hs-CRP are associated with the recurrence of atrial fibrillation in patients with radiofrequency ablationts. NLR value and serum hs-CRP increased are the risk factors of recurrent atrial fibrillation after radiofrequency catheter ablation,which can be used as independent predictors of atrial fibrillation recurrence after radiofrequency ablation.