Analysis of risk factors on mucus formation in children with mycoplasma pneumonia / 中国综合临床

ABSTRACT

Objective To explore the risk factors of Mycoplasma pneumoniae pneumonia ( MPP ) combined with mucous plug in children. Methods A retrospective analysis was carried out on the clinical data of one hundred and forty-nine patients with MMP who received fiber bronchoscope from September 2013 to September 2016. Based on the airway mucosal lesions seen through the bronchoscope,patients were divided into two groupsthe mucous plug group( 82 cases) and the control group( 67 cases) . The risk factors of mucous plug in MMP children were analyzed through single factor and multifactor analysis. Area under curve ( AUC ) was calculated according to receiver operator characteristic ( ROC ) curve to evaluate the diagnostic value of independent risk factor. Results The result of univariate analysis showed that,in the mucous plug group,the age was (5.88±2.01)ages,pleural effusion cases was 64.63％,febrile course was (10.65±2.87)d,CRP was (50. 99±20. 23) mg/L,serum LDH was (429. 94±160. 28)U/L,significantly higher than those in the control group ( age(5. 12±2. 15)ages,pleural effusion cases was 28. 36％,febrile course was(8. 97±3. 01)d,CRP was (20. 89±9. 98) mg/L and serum LDH was(300. 12±125. 14)U/L),the differences were statistically significant (P<0. 05) . Multiple factors analysis showed that age of onset, febrile course, CRP, serum LDH were the independent risk factors, the differences were statistically significant ( 95％CI= 2. 054 ～ 18. 305, 1. 539 ～21. 778,1. 159 ～ 24. 565,1. 883 ～ 9. 469,P<0. 05) . . ROC curve analysis indicated that the AUC of CRP and LDH was 0. 897,0. 829,respectively. Conclusion Old age,long febrile course,and high level of CRP and LDH are the independent risk factors for the mucous plug formation in MPP children. The diagnostic value of CRP is higher than that of LDH. Monitoring these factors can help the doctor determine whether the patient need do bronchoscope without delay and prevent the formation of mucous plug and improve the prognosis.