Clinical significance of smooth pursuit eye movement in PD patients / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the clinical significance of smooth pursuit eye movement (SPEM) in primary PD patients.Methods Thirty-two PD patients admitted to our hospital served as a PD group and 30 subjects underging physical examination in our hospital served as a control group in this study.The added SPEM value,types of PD patients,and tremor fraction were recorded.The added SPEM values in different types of PD patients were compared between the two groups.The influencing factors for added SPEM values were analyzed by multivariate linear regression analysis.The added SPEM values were analyzed by ROC curve analysis in PD patients.Results The added SPEM value was significantly lower in PD group than in control group (0.80±0.11 vs 0.91± 0.13,P=0.001).The added SPEM value was significantly different in 3 types of PD patients (P=0.027).The added SPEM value was significantly lower in PD patients with dominant tremor than in those with posture unstable gait (0.7±0.1 vs 0.8±0.1,P＜0.01).The added SPEM value was negatively related with the tremor fraction (P =0.000).The sensitivity and specificity of added SPEM value in diagnosis of PD were 79.2 ％ and 87.5 ％ respectively.The area under the ROC curve was 0.807 (95％ CI.0.641-0.973,P =0.010).Conclusion The SPEM function is significantly poorer in PD patients with dominant tremor than in those without tremor.The added SPEM value can thus used as a rather good indicator for differential diagnosis of dominant tremor from that of non-dominant tremor in PD patients.