Effect of intensive atorvastatin therapy on blood glucose in acute coronary syndrome patients / 中华老年心脑血管病杂志

ABSTRACT

Objective To study the effect of intensive atorvastatin therapy on blood glucose in ACS patients.Methods Two hundred ACS patients were divided into control group (n=100) and intensive atorvastatin therapy group (n=100).The patients in both groups underwent secondary preventive treatment of CHD.The patients in control group were treated with 20 mg oral atorvastatin before going to bed and those in intensive atorvastatin therapy group were treated with 40mg oral atorvastatin.The patients were followed up for 6 months,during which their serum levels of FPG,HbA1c,TC,TG,LDL-C and HDL-C were measured before and after treatment.Results The serum levels of HDL-C were significantly higher while those of TC,TG and LDL-C were significantly lower in control group after treatment than before treatment (P＜0.01).The serum levels of HDL-C,FPG and HbA1c were significantly higher while those of TC,TG and LDL-C were significantly lower in intensive atorvastatin therapy group after treatment than before treatment(P＜0.05,P＜0.01).The serum levels of HDL-C,FPG and HbA1c were significantly higher while those of TC and LDL-C were significantly lower in intensive atorvastatin therapy group after treatment than before treatment (1.48±0.39 mmol/L vs 1.36±0.20 mmol/L,P＜0.05;5.71±0.67 mmol/L vs 5.21±0.53 mmol/L,P＜0.01;5.44％±0.75％ vs 5.19％±0.31％,P＜0.01).Conclusion Intensive statin therapy can effectively reduce the serum lipid level,elevate the serum FPG level,and increase the risk of diabetes in ACS patients.