Association of preoperative serum albumin level with clinicopathologic features and prognosis in gastric stump cancer / 中华普通外科杂志

ABSTRACT

Objective To evaluate the clinicopathologic characteristics and prognosis of gastric stump cancer in relation to serum albumin level.Methods The clinical data of 149 gastric stump cancer patients treated from Jan 1999 to Jun 2015 were analyzed.Patients were divided into normal serum albumin group (＞ 35 g/L,n =81) and group of hypoalbuminemia (≤ 35 g/L,n =68).Results Clinicopathologic characteristics,tumor size,depth of invasion,lymph node status and TNM stage were significantly different between the two groups (P ＜ 0.05).Univariate analysis showed that factors that influence prognosis were serum albumin level,tumor size,serosal invasion,tumor location and tumor curative resection rate (all P ＜ 0.05).Cox's proportional hazard regression model showed that serum albumin level and tumor curative resection rate were independent prognostic factors for survival,lymph node matastasis(2.2 ±4.3) vs.(4.1 ±4.4)were significantly different between the two groups (P ＜0.05).The overall 5-year survival rate was 44.1％.The 5-year survival rate were 54.0％ for normal albumin group and 32.2％ for hypoalbuminemic group,P =0.011.Conclusion Lower preoperative serum albumin level is associated with poorer prognosis in gastric stump cancer patients.