Meta-analysis of B-type natriuretic peptide and prognosis of maintenance hemodialysis patients / 中华肾脏病杂志

ABSTRACT

Objective To determine whether elevated circulating B-type natriuretic peptide (BNP) or N-terminal B-type natriuretic peptide precursor (NT-proBNP) could predict long-term risks of all-cause mortality,cardiovascular mortality or cardiovascular events among maintenance hemodialysis (MHD) patients.Method Data updated by December 2014 in Cochrane Library,Medline Database,Embase Database,CBMdisc and CEBM/CCD were searched.Related research about the relation of BNP or NT-proBNP and the prognosis of MHD patients were included,regardless of language or whether blind method was used.The data were extracted independently by two reviewers.The methodological quality of trails was assessed by recommended evaluation standard.Statistical analysis was performed with STATA 10.0.Results There were 874 papers found by our search strategy,among which 711 articles were in English and 163 articles were in Chinese.Nineteen papers were eligible according to the inclusion criterion and a total of 6185 cases were included.The Meta-analysis results showed that:(1) Elevated BNP or NT-proBNP was significantly related to increased all-cause mortality (HR:2.64,95％ CI:1.73-4.02);(2) Elevated BNP or NT-proBNP was associated with increased cardiovascular events (HR:5.35-7.04,95％ CI:2.23-22.33).Conclusion BNP or NT-proBNP is a promising prognostic tool to risk-stratify MHD patients.