Spinal GLP-1 Receptor/IL-10/β-endorphin Pathway and It's Relation with Lamiophlomis rotate Analgesia / 中山大学学报(医学科学版)

ABSTRACT

Glucagon-like peptide-1 (GLP-1) receptors belong to the class B of G protein coupled-receptors and are expressed in pancreas,lungs,GI tract,kidneys,heart and the central nervous system.During episodes of hyperglycemia activation of GLP-1 receptors located on pancreas islet β-cells facilitates insulin release and increases insulin sensitivity to regulate blood sugar.In the central nervous system,activation of GLP-1 receptors produces neuroprotection and analgesia.In this mini-review,we have summarized our recent work1) identification of microglial GLP-1 receptor/IL-10/ β-endorphin pathway in the spinal cord;2) discovery of the mechanisms of activation of GLP-1 receptors by which analgesic Lamiophlomis rotata and its effective ingredients iridoid glycosides produce antinociception.Our work highlight that spinal microglial GLP-1 receptor might be a human-demonstrated target for the treatment of chronic pain.