Clinical characteristics and outcomes of placental site trophoblastic tumor: experience of single institution in Korea
Obstetrics & Gynecology Science
; : 319-327, 2018.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-714712
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
Placental site trophoblastic tumor (PSTT) is the rarest form of gestational trophoblastic disease (GTD) and the optimum management is still controversial. In this study, we analyzed the clinical features, treatment, and outcomes of 6 consecutive patients with PSTT treated in our institution.METHODS:
The electronic medical record database of Samsung Medical Center was screened to identify patients with PSTT from 1994 to 2017. Medical records for the details of each patient's clinical features and treatment were extracted and reviewed. This study was approved Institutional Review Board of our hospital.RESULTS:
A total of 418 cases of GTD, 6 (1.4%) patients with PSTT were identified. The median age of the patients was 31 years. The antecedent pregnancy was term in all 5 cases with available antecedent pregnancy information and the median interval from pregnancy to diagnosis of PSTT was 8 months. The median titer of serum beta human chorionic gonadotropin (β-hCG) at diagnosis was 190.9 mIU/mL. Five (83.3%) patients presented with irregular vaginal bleeding and one (16.7%) had amenorrhea. All patients had disease confined to the uterus without metastasis at diagnosis and were successfully treated by hysterectomy alone. All of them were alive without disease during the follow-up period.CONCLUSION:
In this study, we observed low level serum β-hCG titer and irregular vaginal bleeding with varying interval after antecedent term pregnancy were most common presenting features of PSTT. In addition, we demonstrated hysterectomy alone was successful for the treatment of stage I disease of PSTT.
Texto completo:
Disponível
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas
Problema de saúde:
Objetivo 6: Sistemas de informação em saúde
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Prognóstico
/
Hemorragia Uterina
/
Útero
/
Prontuários Médicos
/
Seguimentos
/
Tumor Trofoblástico de Localização Placentária
/
Comitês de Ética em Pesquisa
/
Doença Trofoblástica Gestacional
/
Diagnóstico
/
Registros Eletrônicos de Saúde
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Estudo prognóstico
Limite:
Feminino
/
Humanos
/
Gravidez
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Obstetrics & Gynecology Science
Ano de publicação:
2018
Tipo de documento:
Artigo