Evaluation of bone mineral status in prepuberal children with newly diagnosed type 1 diabetes
Annals of Pediatric Endocrinology & Metabolism
; : 136-140, 2018.
Article
em En
| WPRIM
| ID: wpr-716850
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: Many studies have reported that patients with type 1 diabetes have reduced bone mineral density (BMD). We assessed bone status in prepubertal children with type 1 diabetes mellitus (type 1 DM) at initial diagnosis and investigated factors associated with BMD. METHODS: Prepubertal children (n=29) with newly diagnosed type 1 diabetes from 2006 to 2014 were included. Dual-energy X-ray absorptiometry measured regional and whole-body composition at initial diagnosis. BMD was compared with healthy controls matched for age, sex, and body mass index (BMI). RESULTS: The mean age of all subjects (16 boys and 13 girls) was 7.58±1.36 years (range, 4.8–11.3 years). Initial mean glycosylated hemoglobin (HbA1c) level was 12.2%±1.9%. The mean BMD z-scores of lumbar spine, femur neck, and total body were not significantly different between patients and controls. Three patients (10.3%) had low bone density (total body BMD standard deviation score [SDS] < -2.0). To identify determinants of lumbar spine BMD z-score, multivariate regression analysis was performed with stepwise variable selection of age, pubertal status, BMI SDS, insulin like growth factor-1, and HbA1c. Only BMI SDS was significantly correlated with lumbar spine BMD z-score (β=0.395, P=0.023). CONCLUSIONS: Prepubertal children with newly diagnosed type 1 DM had similar bone mass compared to healthy peers. However, patients with low BMI should be carefully monitored for bone density in type 1 DM.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Coluna Vertebral
/
Hemoglobinas Glicadas
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Absorciometria de Fóton
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Índice de Massa Corporal
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Densidade Óssea
/
Diabetes Mellitus Tipo 1
/
Diagnóstico
/
Colo do Fêmur
/
Mineradores
/
Insulina
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Child
/
Humans
Idioma:
En
Revista:
Annals of Pediatric Endocrinology & Metabolism
Ano de publicação:
2018
Tipo de documento:
Article