Minimal Change Disease in Systemic Lupus: Another Renal Manifestation of Lupus? / 이화의대지
The Ewha Medical Journal
; : 139-143, 2013.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-71796
Biblioteca responsável:
WPRO
ABSTRACT
Nephrotic syndrome is most commonly observed in membranous lupus nephritis in patients with systemic lupus erythematosus (SLE). However, other forms of idiopathic nephrotic syndrome rarely occur in these patients. Here, we report a case of SLE complicated by minimal change disease (MCD). A 24-year-old woman with SLE visited our hospital for generalized edema and heavy proteinuria. Laboratory tests did not support immunological exacerbation of lupus, while renal biopsy revealed diffusely effaced foot processes without electron-dense deposits that were consistent with MCD. Administration of high-dose corticosteroids and 6 subsequent cycles of monthly intravenous cyclophosphamide resulted in complete remission. Although nephrotic-range proteinuria recurred 1 month after switching to maintenance therapy with mycophenolate mofetil, complete remission was reestablished after a 6-month treatment with corticosteroids and cyclosporine. Physicians should be cautious in assessment and management of such a rare renal manifestation.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Proteinúria
/
Biópsia
/
Nefrite Lúpica
/
Ciclosporina
/
Corticosteroides
/
Ciclofosfamida
/
Edema
/
Lúpus Eritematoso Sistêmico
/
Ácido Micofenólico
/
Nefrose Lipoide
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
The Ewha Medical Journal
Ano de publicação:
2013
Tipo de documento:
Artigo