New Insights into the Role of Endoplasmic Reticulum Stress in Breast Cancer Metastasis / 한국유방암학회지
Journal of Breast Cancer
; : 354-362, 2018.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-718898
Biblioteca responsável:
WPRO
ABSTRACT
Cellular stress severely disrupts endoplasmic reticulum (ER) function, leading to the abnormal accumulation of unfolded or misfolded proteins in the ER and subsequent development of endoplasmic reticulum stress (ERS). To accommodate the occurrence of ERS, cells have evolved a highly conserved, self-protecting signal transduction pathway called the unfolded protein response. Notably, ERS signaling is involved in the development of a variety of diseases and is closely related to tumor development, particularly in breast cancer. This review discusses recent research regarding associations between ERS and tumor metastasis. The information presented here will help researchers elucidate the precise mechanisms underlying ERS-mediated tumor metastasis and provide new directions for tumor therapies.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Mama
/
Neoplasias da Mama
/
Transdução de Sinais
/
Retículo Endoplasmático
/
Resposta a Proteínas não Dobradas
/
Estresse do Retículo Endoplasmático
/
Metástase Neoplásica
Idioma:
Inglês
Revista:
Journal of Breast Cancer
Ano de publicação:
2018
Tipo de documento:
Artigo