Efficacy and Safety of Secukinumab for the Treatment of Moderate to Severe Psoriasis in Korea / 대한피부과학회지
Korean Journal of Dermatology
; : 9-14, 2019.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-719530
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Secukinumab, a fully human monoclonal antibody that targets interleukin (IL)-17A, which is a central cytokine in the pathogenesis of psoriasis, has emerged as a promising treatment for moderate to severe psoriasis. However, to date, there are no real-world data for secukinumab in Korean patients with psoriasis.OBJECTIVE:
To assess the clinical efficacy and safety of secukinumab in Korean patients with psoriasis.METHODS:
Prospective data were gathered during follow-up from 28 consecutive patients with chronic plaque-type psoriasis treated with secukinumab for minimum of 12 weeks at a single referral center. Patient demographics, Psoriasis Area Severity Index (PASI) score, Physicians' Global Assessment (PGA), Dermatologic Life Quality Index (DLQI), and adverse events were investigated.RESULTS:
The mean PASI score was significantly decreased after the induction period of secukinumab treatment (paired t-test, p<0.05). Of the 28 patients, 17 (60.7%) had obtained near complete clearance (PASI 90) at the last follow-up visit. No unexpected adverse events, other than nasopharyngitis, were observed.CONCLUSION:
Secukinumab can be of benefit for the treatment of Korean patients with psoriasis, as the treatment was associated with a rapid and satisfactory response and safety profile.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Psoríase
/
Qualidade de Vida
/
Encaminhamento e Consulta
/
Demografia
/
Nasofaringite
/
Estudos Prospectivos
/
Seguimentos
/
Interleucinas
/
Resultado do Tratamento
/
Coreia (Geográfico)
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Aspecto:
Determinantes sociais da saúde
/
Preferência do paciente
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Korean Journal of Dermatology
Ano de publicação:
2019
Tipo de documento:
Artigo