Clinical Phenotype of a First Unprovoked Acute Pulmonary Embolism Associated with Antiphospholipid Antibody Syndrome / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 53-61, 2019.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-719617
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Antiphospholipid antibody syndrome (APS), an important cause of acquired thrombophilia, is diagnosed when vascular thrombosis or pregnancy morbidity occurs with persistently positive antiphospholipid antibodies (aPL). APS is a risk factor for unprovoked recurrence of pulmonary embolism (PE). Performing laboratory testing for aPL after a first unprovoked acute PE is controversial. We investigated if a specific phenotype existed in patients with unprovoked with acute PE, suggesting the need to evaluate them for APS.METHODS:
We retrospectively reviewed patients with PE and APS (n=24) and those with unprovoked PE with aPL negative (n=44), evaluated 2006–2016 at the Asan Medical Center. We compared patient demographics, clinical manifestations, laboratory findings, and radiological findings between the groups.RESULTS:
On multivariate logistic regression analysis, two models of independent risk factors for APS-PE were suggested. Model I included hemoptysis (odds ratio [OR], 12.897; 95% confidence interval [CI], 1.025–162.343), low PE severity index (OR, 0.948; 95% CI, 0.917–0.979), and activated partial thromboplastin time (aPTT; OR, 1.166; 95% CI, 1.040–1.307). Model II included age (OR, 0.930; 95% CI, 0.893–0.969) and aPTT (OR, 1.104; 95% CI, 1.000–1.217).CONCLUSION:
We conclude that patients with first unprovoked PE with hemoptysis and are age <40; have a low pulmonary embolism severity index, especially in risk class I–II; and/or prolonged aPTT (above 75th percentile of the reference interval), should be suspected of having APS, and undergo laboratory testing for aPL.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Tempo de Tromboplastina Parcial
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Fenótipo
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Embolia Pulmonar
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Recidiva
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Trombose
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Modelos Logísticos
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Demografia
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Estudos Retrospectivos
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Fatores de Risco
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Síndrome Antifosfolipídica
Tipo de estudo:
Estudo de etiologia
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Estudo observacional
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Estudo prognóstico
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Fatores de risco
Aspecto:
Determinantes sociais da saúde
Limite:
Humanos
/
Gravidez
Idioma:
Inglês
Revista:
Tuberculosis and Respiratory Diseases
Ano de publicação:
2019
Tipo de documento:
Artigo