Fludarabine-containing chemotherapy for patients with previously untreated low-grade non-Hodgkin's lymphoma
Korean Journal of Hematology
; : 180-185, 2011.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-720288
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
The clinical efficacy and safety of fludarabine combination chemotherapy was investigated for the treatment of previously untreated patients with low-grade (NHL).METHODS:
Twenty-five patients who were newly diagnosed as low-grade NHL were treated with fludarabine combination chemotherapy. Fludarabine combination regimens consisted of fludarabine, mitoxantrone and dexamethasone or fludarabine, cyclophosphamide and mitoxantrone with or without rituximab and repeated every 4 weeks.RESULTS:
The median age was 60 years (range, 35-77 years), with 13 of 25 patients (52%) > or =60 years of age. Seven of 25 patients (28%) with an intermediate risk follicular lymphoma international prognostic index (FLIPI) and 9 of 25 patients (36%) with a high risk FLIPI were enrolled in this study. The delivered median number of chemotherapy was six (range, 2-9 cycles). The overall response rate with fludarabine-based treatment was 88%, including 52% complete remission and 36% partial remission. During the median follow-up of 19 months, the estimated 2-year event-free survival was 63+/-10% (95% CI, 43-83) and the 2-year overall survival was 78+/-9% (95% CI, 60-96). Fludarabine combination chemotherapy was frequently associated with grade 3 or 4 neutropenia in 84% patients. However, neutropenic infection was observed in only one (4%) patient. Four patients (16%) showed grade 3 or more non-hematologic toxicities, such as acute coronary syndrome, intracranial hemorrhage, anaphylaxis and gastric cancer.CONCLUSION:
Fludarabine-combination treatment was a highly active regimen with well toleration in untreated low-grade NHL.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Vidarabina
/
Linfoma não Hodgkin
/
Dexametasona
/
Seguimentos
/
Linfoma Folicular
/
Mitoxantrona
/
Intervalo Livre de Doença
/
Hemorragias Intracranianas
/
Ciclofosfamida
/
Quimioterapia Combinada
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Limite:
Humanos
Idioma:
Inglês
Revista:
Korean Journal of Hematology
Ano de publicação:
2011
Tipo de documento:
Artigo