In vitro Activities of Mecillinam Against Clinical Isolates of Enterobacteriaceae / 감염과화학요법
Infection and Chemotherapy
; : 174-180, 2009.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-721617
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Mecillinam, an amidinopenicillin antibiotic, has been used to treat urinary tract infections and bacterial enteritis in many countries. In this study, we evaluated in vitro activity of mecillinam against Enterobacteriaceae isolates from urine, and Salmonella and Shigella isolates from patients with bacterial gastroenteritis. MATERIALS ANDMETHODS:
A total of 308 clinical strains were collected and were comprised of Escherichia coli (n=109), Klebsiella pneumoniae (n=52), Enterobacter spp. (n=30), Serratia marcescens (n=30) and Proteus spp. (n=29) isolated from a university hospital in Korea in 2007, and of Salmonella spp. (n=28) and Shigella spp. (n=30) isolated from Korean diarrheal patients from 2001 to 2006. Antimicrobial susceptibility was tested by Clinical Laboratory Standard Institute (CLSI) agar dilution method. CLSI breakpoint of mecillinam for E. coli urinary tract isolates was applied to all other isolates.RESULTS:
In E. coli, rate of susceptibility to ampicillin was 30%, but 99-100% to amikacin and cefotaxime. Most (96%) of E. coli isolates, including extended-spectrum beta-lactamase (ESBL) producers, were susceptible to mecillinam. All ESBL producers, except for one isolate, were inhibited by 128 microg/mL and most of them were resistant to mecillinam. All Salmonella isolates and 27 of 30 Shigella isolates were susceptible to mecillinam.CONCLUSION:
Mecillinam was active in vitro against most Enterobacteriaceae, Salmonella, and Shigella isolates except for S. marcescens. Therefore, mecillinam can be a good alternative agent for treating urinary tract infection and bacterial gastroenteritis.
Texto completo:
Disponível
Contexto em Saúde:
Doenças Negligenciadas
Problema de saúde:
Doenças Negligenciadas
/
Zoonoses
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Pneumonia
/
Proteus
/
Salmonella
/
Serratia marcescens
/
Shigella
/
Sistema Urinário
/
Infecções Urinárias
/
Beta-Lactamases
/
Amicacina
/
Cefotaxima
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Infection and Chemotherapy
Ano de publicação:
2009
Tipo de documento:
Artigo