Optimal Timing of Zoster Vaccination After Shingles: A Prospective Study of the Immunogenicity and Safety of Live Zoster Vaccine / 감염과화학요법
Infection and Chemotherapy
; : 311-318, 2018.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-722315
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND:
Zoster vaccination is recommended for people with a history of herpes zoster (HZ), but the most effective timing of vaccine administration after zoster illness is unresolved. This prospective observational study compared the immunogenicity and safety of administering HZ vaccine at 6-12 months and 1-5 years after zoster illness. MATERIALS ANDMETHODS:
Blood samples were collected before the administration of live zoster vaccine and 6 weeks after vaccination. Varicella-zoster virus (VZV) IgG concentrations and T-cell responses were assessed by glycoprotein enzyme-linked immunosorbent assay and interferon-γ enzyme-linked immunospot assay (ELISPOT), respectively.RESULTS:
The baseline geometric mean value (GMV) of VZV IgG was higher in the 6-12 months group than in the 1-5 years group (245.5 IU/mL vs. 125.9 IU/mL; P = 0.021). However, the GMV increased significantly in both groups (P = 0.002 in the 6-12 months group; P 1 year after zoster illness. TRIAL REGISTRATION ClinicalTrials.gov Identifier NCT02704572
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Saúde e Bem-Estar
Problema de saúde:
Meta 3.3: Acabar com as doenças tropicais negligenciadas e combater as doenças transmissíveis
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Imunoglobulina G
/
Ensaio de Imunoadsorção Enzimática
/
Glicoproteínas
/
Linfócitos T
/
Estudos Prospectivos
/
Vacinação
/
Herpesvirus Humano 3
/
Vacina contra Herpes Zoster
/
ELISPOT
/
Estudo Observacional
Tipo de estudo:
Estudo observacional
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Infection and Chemotherapy
Ano de publicação:
2018
Tipo de documento:
Artigo