Probable Interaction between Warfarin and Baclofen: A report of two cases
Journal of the Korean Academy of Rehabilitation Medicine
; : 761-764, 1998.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-724142
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To present two cases of probable warfarin and baclofen interactions which occurred during the concomitant drug administrations. CASESUMMARY:
In the first case, a 55-year-old man with C6 ASIA C receiving 80 mg/day of baclofen was prescribed 5 mg/day of warfarin after heparinization for the treatment of deep vein thrombosis of the left external iliac vein. After the third day of warfarin administration, the patient exhibited cognitive dysfunction. Within one week after initiation of warfarin, the INR increased to 4.4, with increased cognitive dysfunction. After the stop of warfarin, the return of the INR to baseline took six days. In the second case, a 45-year-old man with a spastic right hemiplegia from a stroke and a history of myocardial infarction was on 5 mg/day of warfarin for two years. When forty-five mg of baclofen was added, the patient developed a nausea, fatigue, and confusion after three days. The INR increased to 4.5 at eight days after the baclofen was added, despite the diminished dosage of warfarin.CONCLUSION:
These two cases suggest a probable warfarin-baclofen interaction. Attention should be given to the patients who concomitantly use the warfarin and baclofen to protect the patient from harmful drug interactions.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Ásia
/
Baclofeno
/
Varfarina
/
Heparina
/
Coeficiente Internacional Normatizado
/
Trombose Venosa
/
Acidente Vascular Cerebral
/
Interações Medicamentosas
/
Fadiga
/
Hemiplegia
Limite:
Humanos
País/Região como assunto:
Ásia
Idioma:
Coreano
Revista:
Journal of the Korean Academy of Rehabilitation Medicine
Ano de publicação:
1998
Tipo de documento:
Artigo