Animal Models of Demyelination and ¹H-Magnetic Resonance Spectroscopy
Journal of the Korean Society of Biological Psychiatry
; : 1-9, 2017.
Artigo
em Coreano
| WPRIM (Pacífico Ocidental)
| ID: wpr-725019
Biblioteca responsável:
WPRO
ABSTRACT
The proton magnetic resonance spectroscopy (¹H-MRS) is a tool used to detect concentrations of brain metabolites such as N-acetyl aspartate, choline, creatine, glutamate, and gamma-amino butyric acid (GABA). It has been widely used because it does not require additional devices other than the conventional magnetic resonance scanner and coils. Demyelination, or the neuronal damage due to loss of myelin sheath, is one of the common pathologic processes in many diseases including multiple sclerosis, leukodystrophy, encephalomyelitis, and other forms of autoimmune diseases. Rodent models mimicking human demyelinating diseases have been induced by using virus (e.g., Theiler's murine encephalomyelitis virus) or toxins (e.g., cuprizon or lysophosphatidyl choline). This review is an overview of the MRS findings on brain metabolites in demyelination with a specific focus on rodent models.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Processos Patológicos
/
Roedores
/
Doenças Autoimunes
/
Análise Espectral
/
Encéfalo
/
Colina
/
Doenças Desmielinizantes
/
Ácido Aspártico
/
Ácido Glutâmico
/
Ácido Butírico
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
/
Humanos
Idioma:
Coreano
Revista:
Journal of the Korean Society of Biological Psychiatry
Ano de publicação:
2017
Tipo de documento:
Artigo