Autoimmune Hemolytic Anemia Predominantly Associated with IgA Anti-E and Anti-c
Journal of Korean Medical Science
; : 708-711, 2002.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-72653
Biblioteca responsável:
WPRO
ABSTRACT
A patient with warm autoimmune hemolytic anemia (AIHA) due to predominance of immunoglobulin A (IgA) with an Rh specificity, considered to be the first case in Korea, is described. A 13-yr-old male patient with severe hemolytic anemia showed a weak reactivity (1+) in the direct antiglobulin test (DAT) by using anti-IgG antiglobulin reagent. This finding, however, could not fully explain the patient's severe AIHA. When anti-IgA reagent was used for the DAT, strong reactivity (4+) was observed and free anti-E and anti-c autoantibodies were also detected by anti-IgA and anti-IgG reagents. The patient's hemoglobin began to rise with the administration of steroids. Because RBCs coated with multiple types of immunoglobulins are associated with more severe hemolysis than those only with IgG, the DATs using anti-IgA and other reagents are needed for the correct diagnosis when the result of DAT is not compatible with patient's clinical manifestations.
Texto completo:
Disponível
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Sistema do Grupo Sanguíneo Rh-Hr
/
Autoanticorpos
/
Imunoglobulina A
/
Teste de Coombs
/
Anemia Hemolítica Autoimune
/
Coreia (Geográfico)
/
Especificidade de Anticorpos
Limite:
Adolescente
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Journal of Korean Medical Science
Ano de publicação:
2002
Tipo de documento:
Artigo