Decursin induces apoptosis in glioblastoma cells, but not in glial cells via a mitochondria-related caspase pathway
The Korean Journal of Physiology and Pharmacology
; : 29-35, 2019.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-728028
Biblioteca responsável:
WPRO
ABSTRACT
Decursin is a major biological active component of Angelica gigas Nakai and is known to induce apoptosis of metastatic prostatic cancer cells. Recently, other reports have been commissioned to examine the anticancer activities of this plant. In this study, we evaluated the inhibitory activity and related mechanism of action of decursin against glioblastoma cell line. Decursin demonstrated cytotoxic effects on U87 and C6 glioma cells in a dose-dependent manner but not in primary glial cells. Additionally, decursin increased apoptotic bodies and phosphorylated JNK and p38 in U87 cells. Decursin also down-regulated Bcl-2 as well as cell cycle dependent proteins, CDK-4 and cyclin D1. Furthermore, decursin-induced apoptosis was dependent on the caspase activation in U87 cells. Taken together, our data provide the evidence that decursin induces apoptosis in glioblastoma cells, making it a potential candidate as a chemotherapeutic drug against brain tumor.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Neoplasias do Cérebro e Sistema Nervoso
/
Neoplasia da Próstata
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas
/
Neoplasias da Próstata
/
Neoplasias Encefálicas
/
Ciclo Celular
/
Linhagem Celular
/
Neuroglia
/
Apoptose
/
Glioblastoma
/
Ciclina D1
/
Angelica
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2019
Tipo de documento:
Artigo