Assessment of an Apo-1/Fas Promoter Polymorphism in Korean Schizophrenia Patients
The Korean Journal of Physiology and Pharmacology
; : 161-164, 2002.
Artigo
em Inglês
| WPRIM (Pacífico Ocidental)
| ID: wpr-728055
Biblioteca responsável:
WPRO
ABSTRACT
Apoptosis has been hypothesized to be involved in the pathogenesis in schizophrenia. A large number of genes are known to mediate the apoptotic process; Apo-1/Fas (CD95) is a well-known example of such genes. In the present study, MvaI restriction fragment length polymorphism, a polymorphic marker present within the Apo-1/Fas gene, was examined in a population consisting of 226 control subjects and 110 schizophrenia patients, all of them Korean in ethnicity. No statistically significant difference in the genotypic distribution and allelic frequencies was observed between the control and the schizophrenia patient group. To find out the precise effect of Apo-1/Fas gene polymorphisms on the susceptibility to schizophrenia, further studies are warranted to investigate possible involvement of other polymorphisms with a larger sample population.
Texto completo:
Disponível
Contexto em Saúde:
ODS3 - Meta 3.4 Reduzir as mortes prematuras devido doenças não transmissíveis
Problema de saúde:
Saúde Mental e Transtornos do Comportamento
Base de dados:
WPRIM (Pacífico Ocidental)
Assunto principal:
Esquizofrenia
/
Polimorfismo de Fragmento de Restrição
/
Regiões Promotoras Genéticas
/
Apoptose
Limite:
Humanos
Idioma:
Inglês
Revista:
The Korean Journal of Physiology and Pharmacology
Ano de publicação:
2002
Tipo de documento:
Artigo